The All India Institute of Medical Sciences [AIIMS] was designed to serve as a nucleus for nurturing excellence in all aspects of health and wellness program throughout India. AIIMS are a group of autonomous public medical institutes that have been declared by an Act of Parliament 1956 as “Institute of National Importance”. AIIMS Mangalagiri is one of the AIIMS healthcare institutes being established by the Ministry of Health & Family Welfare, Government of India under the Pradhan Mantri Swasthya Suraksha Yojna (PMSSY). With the aim of correcting regional imbalances in quality tertiary level healthcare in the country, and attaining self sufficiency in graduate and postgraduate medical education and training the PMSSY planned to set up new AIIMS like institutions in under served areas of the country.

In 2018, AIIMS, Mangalagiri started functioning from a newly constructed, albeit temporary campus at Government Siddhartha Medical College, Vijayawada. In March 2019 OPD services was started in the Permanent campus at Mangalagiri, Guntur. Therafter AIIMS gradually moved into its designated campus as newly constructed .During the Lockdown during COVID19 pandemic, OPD services were supplemented with eParamarsh initiative for doorstep sample collection. For COVID19 positive pateints limted IPD services  started during 2020. In early part of 2021 limited IPD services for other patients have started.

The 2018 and 2019 MBBS batch of 50 students each started their first year in the temporary campus at Vijayawada. The 2020 batch of 125 MBBS students have started their academics in Mangalagiri from day 1.